aqueous extract of berberis integerrima root improves renal dysfunction in streptozotocin induced diabetic rats

نویسندگان

reza heidari department of biology, faculty of science, urmia university, urmia, i. r. iran

vahid nejati department of biology, faculty of science, urmia university, urmia, i. r. iran

minoo ilkhanipoor department of biology, faculty of science, urmia university, urmia, i. r. iran

چکیده

objective: barberry root extract contains various alkaloids that are considered as antioxidants. beneficial effect of aqueous extract of berberis integerrima root (aebir) was evaluated for renal function in diabetic rats induced by stz. material and methods: diabetes was induced by i.p. injection of streptozotocin (65 mg/kg bw) to rats, after 15 h of fasting. diabetic rats were randomly grouped and treateddaily with aebir and glibenclamide by gavage for 42 days. after 6 weeks of study, all the rats were sacrificed and some biochemical parameters of serum and urine were measured and their kidneys tissues were processed for light microscopy. results: streptozotocin induced a significant rise in fasting blood glucose, serum creatinine, blood urea nitrogen, urine glucose, urine protein, urine albumin, and water intake and a significant decrease in body weight, serum protein, urine urea, and urine creatinine. there was a significant restoration of these parameters to near normal after administration of the aebir and also by glibenclamide (0.6 mg/kg bw). the activity of the extract at dose of 500 mg/kg in all parameters except blood glucose and urine glucose was more than that of the standard drug, glibenclamide (0.6 mg/kg, p.o.). histopathological changes of kidney samples were comparable with respective control. conclusion: these results suggested that aqueous extract of berberis integerrima root improves renal dysfunction in streptozotocin-induced diabetic rats through controlling blood glucose and renal protective effects.

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منابع مشابه

Aqueous extract of Berberis integerrima root improves renal dysfunction in streptozotocin induced diabetic rats

Objective: Barberry root extract contains various alkaloids that are considered as antioxidants. Beneficial effect of aqueous extract of Berberis integerrima root (AEBIR) was evaluated for renal function in diabetic rats induced by STZ. Material and Methods: Diabetes was induced by i.p. injection of streptozotocin (65 mg/kg bw) to rats, after 15 h of fasting. Diabetic rats were randomly grouped...

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Aqueous extract of Berberis integerrima root improves renal dysfunction in streptozotocin induced diabetic rats

OBJECTIVE Barberry root extract contains various alkaloids that are considered as antioxidants. Beneficial effect of aqueous extract of Berberis integerrima root (AEBIR) was evaluated for renal function in diabetic rats induced by STZ. MATERIAL AND METHODS Diabetes was induced by i.p. injection of streptozotocin (65 mg/kg bw) to rats, after 15 h of fasting. Diabetic rats were randomly grouped...

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Effects of Aqueous Extract of Berberis integerrima Root on Some Physiological Parameters in Streptozotocin-Induced Diabetic Rats

Diabetes mellitus is a common endocrine disorder. Anti-diabetic agents from natural and synthetic sources are available for the treatment of this disease. Berberis integerrima is a medicinal shrub used in conventional therapy for a number of diseases. The aim of the present study was to investigate the effects of aqueous extract of Berberis integerrima root (AEBI) on some physiological paramete...

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Effects of Aqueous Extract of Berberis integerrima Root on Some Physiological Parameters in Streptozotocin-Induced Diabetic Rats

Diabetes mellitus is a common endocrine disorder. Anti-diabetic agents from natural and synthetic sources are available for the treatment of this disease. Berberis integerrima is a medicinal shrub used in conventional therapy for a number of diseases. The aim of the present study was to investigate the effects of aqueous extract of Berberis integerrima root (AEBI) on some physiological paramete...

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Effects of Aqueous Extract of Berberis integerrima Root on Some Physiological Parameters in Streptozotocin-Induced Diabetic Rats

Diabetes mellitus is a common endocrine disorder. Anti-diabetic agents from natural and synthetic sources are available for the treatment of this disease. Berberis integerrima is a medicinal shrub used in conventional therapy for a number of diseases. The aim of the present study was to investigate the effects of aqueous extract of Berberis integerrima root (AEBI) on some physiological paramete...

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effects of aqueous extract of berberis integerrima root on some physiological parameters in streptozotocin-induced diabetic rats

diabetes mellitus is a common endocrine disorder. anti-diabetic agents from natural and synthetic sources are available for the treatment of this disease. berberis integerrima is a medicinal shrub used in conventional therapy for a number of diseases. the aim of the present study was to investigate the effects of aqueous extract of berberis integerrima root (aebi) on some physiological paramete...

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عنوان ژورنال:
avicenna journal of phytomedicine

جلد ۳، شماره ۱، صفحات ۸۲-۹۰

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